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OBSERVATIONS ON HEPARIN‐INDUCED CLEARING ACTIVITY IN ISCHÆMIC HEART DISEASE AND THE EFFECT OF PROLONGED HEPARIN THERAPY
Author(s) -
NESTEL P. J.
Publication year - 1961
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1961.10.1.29
Subject(s) - heparin , medicine , myocardial infarction , cardiology , platelet
Summary Inhibition of heparin‐induced plasma‐clearing activity has been compared in patients with ischæmic heart disease and age‐matched control subjects. It has been found that the increased inhibitory activity of the plasma of patients with ischæmic heart disease was due to increased inhibitor activity associated with the patients' blood platelets. The inhibitory activities of platelet‐poor plasma were similar in the two groups. It has also been found that heparin‐induced clearing activity was low one month after a myocardial infarction, but increased gradually over the next seven months. The effect of prolonged intermittent heparin therapy on heparin‐induced clearing activity has been studied over a period of seven months in a group of patients who had survived a myocardial infarction. The mean increase in clearing activity was significantly greater in this treated group than in a closely matched group of patients who were not being treated.