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THE FAILURE OF EXPERIMENTAL RENAL TUBULONECROSIS TO PRODUCE OLIGURIA IN THE RAT
Author(s) -
FINCKH E. S.
Publication year - 1960
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1960.9.4.283
Subject(s) - oliguria , anuria , acute tubular necrosis , medicine , acute kidney injury , necrosis , renal artery , diuresis , urology , kidney , anesthesia , renal function
Summary Acute tubulonecrosis was produced in rats by temporary clamping of the renal artery and by the subcutaneous injection of glycerol. Comparison of the mean urinary output of these animals with that of controls, both immediately after the renal damage was initiated and at 24 hours, when tubulonecrosis was clearly established, showed that there was a statistically significant increase rather than a decrease in volume. These results are interpreted as showing that tubulonecrosis itself is not an important cause of oliguria. It is concluded that it is misleading and incorrect to use the term "acute tubular necrosis" as synonymous with the acute anuria syndrome.