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HEREDITY IN PRIMARY GOUT
Author(s) -
EMMERSON B. T.
Publication year - 1960
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1960.9.3.168
Subject(s) - gout , medicine , asymptomatic , heredity , disease , pedigree chart , cousin , incidence (geometry) , pediatrics , genetics , biology , physics , history , archaeology , optics , gene
Summary Two family pedigrees are presented which contain persons homozygous for the gouty trait. In the first family, asymptomatic hyperuricMmia occurred in both parents of a patient with gout of extreme severity and rapid progression. The only relative with clinical gout was a cousin of the patient's mother. In the second family, gout or hyperuricæmia could be traced through five generations. From the union of one of the gouty males of this family and a hyperuricæmic female four hyperuriæmic and gouty children resulted. Three of these children are also hypertensive, and two have evidence of renal impairment. The patient in the index case in the first family had renal disease due to gout itself, while the second family demonstrates that renal disease in gouty subjects may also be due to the association in one family of hyperuricMmia and primary hypertensive vascular disease. Homozygosity for the gouty trait is suggested as a possible cause of gout occurring with undue severity or with an unusually wide family incidence.