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COMPLEMENT FIXATION WITH EXTRACT OF NORMAL THYROID GLAND : ITS OCCURRENCE IN SERA FROM PATIENTS WITH THYROID DISEASE AND IN OTHER CONDITIONS
Author(s) -
HACKETT EARLE,
BEECH MARGARET,
FORBES IAN J.
Publication year - 1960
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1960.9.2.93
Subject(s) - thyroid , complement fixation test , antibody , medicine , thyroglobulin , disease , thyroid disease , immunology , in vivo , endocrinology , pathology , biology , serology , microbiology and biotechnology
Summary Attention is drawn to a complement‐fixing agent which reacts with extract of normal thyroid gland. There are reasons for regarding this agent as an antibody, and possibly as an auto‐antibody. It is significantly associated with thyroid disease, though not so closely as the complement‐fixing anti‐thyrotoxic antibody, or the anti‐thyroglobulin antibody which reacts in the tanned‐cell hæmagglutination technique. It is also associated with some other types of disease, particularly syphilis, the “collagen disease” group, and viral infections. In non‐thyroid diseases, positive reactors are almost equally distributed between the sexes. Any attempted synthesis of the current knowledge of the association between thyroid disease and the presence of serum auto‐antibodies should take this agent into account, even though its activity or significance in vivo may be not entirely confined to the thyroid gland and its functions.