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THE USE OF AN ALDOSTERONE ANTAGONIST IN PATIENTS WITH CIRRHOSIS
Author(s) -
PLAYOUST M. R.,
BLACKBURN C. R. B.
Publication year - 1960
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1960.9.1.64
Subject(s) - aldosterone , ascites , cirrhosis , antagonist , medicine , endocrinology , pathogenesis , urine , excretion , sodium , chemistry , gastroenterology , pharmacology , receptor , organic chemistry
Summary The steroidal spirolactone SC 8109, an aldosterone antagonist, was used in two cases of hepatic disease and ascites resistant to ordinary medical treatment. In both cases there was an increased sodium excretion in the urine, while one of the patients had a significant weight loss and a reduction of her ascites. This substance should prove useful in the further evaluation of aldosterone in the pathogenesis of fluid retention in œdematous states, and possibly in their treatment.