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STUDIES OF FAT METABOLISM IN ATHEROSCLEROSIS BY ISOTOPIC METHODS
Author(s) -
HALL G. V.,
GEORGE E. P.,
HICKIE J. B.
Publication year - 1959
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1959.8.4.307
Subject(s) - lipid metabolism , metabolism , lipid metabolism disorder , medicine , endocrinology , coronary heart disease , blood lipids , chemistry , coronary artery disease , cholesterol , physiology
Summary An isotopic lipid tolerance test is described. An assessment of this test on 40 patients with abnormal lipid metabolism and 12 controls has given the following results : (i) I 131 glyceryl trioleate is a satisfactory tracer of lipid metabolism. (ii) The results of the test are consistent and reproducible. (iii) Patients with coronary atherosclerosis show raised lipid blood radioactivity levels during the first few hours, and these persist to 72 hours, when there is more complete separation between atherosclerotic and normal subjects. (iv) The lipid clearance time is prolonged in almost all patients with coronary heart disease. (v) The results give further support to the apparent linkage of atherosclerosis and disordered lipid metabolism. (vi) The lipid tolerance test described gives a method of assessing the degree of lipid metabolic disorder.