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ACUTE NECROTIZING GLOMERULITIS
Author(s) -
BIALESTOCK DORA,
TANGE J. D.
Publication year - 1959
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1959.8.4.281
Subject(s) - fibrinoid necrosis , polyarteritis nodosa , pathology , medicine , lesion , anuria , necrosis , rapidly progressive glomerulonephritis , glomerulonephritis , glomerulus , kidney , vasculitis , disease
Summary Nine cases of necrotizing glomerulitis have been studied. The lesion was found in association with pulmonary hæmorrhage, or in middle‐aged males with anuria. There were characteristically a low incidence of hypertension and œdema, an insidious onset, a rapid course and a uniformly fatal outcome, usually in urœmia. No causal factors were discovered. The renal lesion consists of necrosis and disintegration of the structure of the glomerular tuft. Cellular proliferation is variable in amount and disorderly. The glomeruli may be replaced by collections of inflammatory and spindle cells or of fibrous tissue. The tubules are spared. The interstitial tissue is œdematous, and may be infiltrated by inflammatory cells. Rarely, renal arteries or arterioles show fibrinoid change without any surrounding inflammatory reaction. Except for pulmonary hœmorrhage in some cases, there are no lesions in other organs. It is concluded that the process shows affinities to both proliferative glomerulonephritis and polyarteritis nodosa, but its exact nature remains to be determined.