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CATION STUDIES DURING INTRAVENOUS ANÆSTHESIA
Author(s) -
HERCUS VICTOR,
BOWMAN SHEILAH
Publication year - 1959
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1959.8.2.117
Subject(s) - potassium , sodium , extracellular , extracellular fluid , chemistry , intracellular , skeletal muscle , liter , medicine , endocrinology , biochemistry , organic chemistry
Summary The effect of pentobarbitone given intravenously on the hæmatocrit, on the serum sodium and potassium contents, and on the intracellular water, sodium and potassium concentrations of skeletal muscle has been investigated in sheep. S 35 O 4 has been used to determine the extracellular space of muscle and the extracellular fluid volume of distribution. A significant fall in serum potassium level (from 5.5 to 4.6 milliequivalents per litre) and in hæmatocrit (from 37.4% to 30.2%) occurred under this anæsthetic agent. There was no change in intracellular water, sodium or potassium concentrations in the extracellular space of skeletal muscle, or in the volume or rate of distribution of S 35 O 4 during anæsthesia. These results were not altered by splenectomy. The administration of adrenaline produced no changes in the hæmatocrit or in the serum potassium level.