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EARLY NEPHRON CHANGES : A MICRODISSECTION STUDY
Author(s) -
BAXTER THELMA J.
Publication year - 1959
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1959.8.1.35
Subject(s) - microdissection , nephron , pathology , kidney , biology , medicine , endocrinology , gene , biochemistry
SUMMARY A kidney, which appeared to be macroscopically normal, obtained from a patient showing no clinical signs of renal disease, was examined by microdissection and showed considerable morphological change. Differences in glomeruli, particularly of shape, and variations in size of proximal convoluted tubules with small diverticula were found ; these changes were not recognized histologically. There were also a few small cysts. These are amongst the earliest stages in the development of well‐known phenomena in the granular kidney demonstrable with our present techniques. A familiarity with gross structural changes, of which these are the rudimentary steps, is essential for the appreciation and prospective study of detailed functional alterations in the component units of the organ.