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THE EFFECT OF TIGLOIDINE ON EXTRAPYRAMIDAL SYNDROMES (HUNTINGTON'S CHOREA)
Author(s) -
TRAUTNER E. M.,
GERSHON S.
Publication year - 1958
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1958.7.4.286
Subject(s) - chorea , habituation , medicine , depression (economics) , drug , spastic , psychiatry , anesthesia , pediatrics , audiology , disease , cerebral palsy , economics , macroeconomics
Summary The tiglic esters of tropine and pseudo‐tropine (tigloidine) were tried in 12 cases of Huntington's chorea. Temporary, occasionally dramatic improvement was obtained in some cases and confirmed by withdrawal of the drug, the use of placebos and renewal of the original medication. The effective dose of the drug varied from case to case and ranged from moo to 400 milligrammes per day. The minimal effective dose was found to be very near to the optimal dose; no further improvement could be obtained by further increasing the dosage. No unpleasant side effects were observed in the subjects treated. No habituation was observed. In no case could all the symptoms of the illness be affected. In some cases mainly the motor disturbances were improved; in others there was mainly an improvement in mood, the patients becoming sometimes distinctly euphoric. The two effects did not seem to be connected, nor was the action of the drug predictable. The results are discussed. The investigation is being extended with the purpose of studying the dual action of the drug. Promising results have so far been observed in cases of pure depression as well as in pure motor‐disturbances (post‐traumatic spinal spastic paraplegias). These results are being prepared for publication.