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A COMPARISON OF THE EARLY METABOLIC EFFECTS OF TRI‐IODOTHYRONINE AND HYDROCORTISONE IN MAN
Author(s) -
HETZEL BASIL S.,
WILLIAMS R.,
LANDER H.
Publication year - 1957
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1957.6.3.218
Subject(s) - hydrocortisone , endocrinology , medicine , triiodothyronine , excretion , potassium , chemistry , urine , hormone , phosphate , sodium , biochemistry , organic chemistry
SUMMARY The early metabolic effects of intravenous triiodothyronine and hydrocortisone have been studied in five healthy male volunteers over a ten‐hour period. Triiodothyronine (0.5 and 1.0 milligramme) produced a rise in metabolic rate with a fall in non‐protein respiratory quotient in three hours. This was associated with an increase in serum and urinary inorganic phosphate content but no increase in total nitrogen or electrolyte excretion. Hydrocortisone (50 milligrammes) produced a rise in potassium excretion after two hours, followed by a retention of sodium. There was an initial retention followed by an increase in urinary excretion of phosphate associated with a rise in serum inorganic phosphate content. There was also a rise in serum cholesterol content. These changes have been compared with those associated with stress in man. Though neither hormone reproduced the full stress pattern, each reproduces some of the changes, and hence they may both be involved in their mechanism.