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HYPOGLYCÆMIC SULPHONAMIDES IN THE MANAGEMENT OF DIABETES MELLITUS
Author(s) -
DOWNIE EWEN,
BORNSTEIN JOSEPH,
HUDSON BRYAN
Publication year - 1957
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1957.6.2.105
Subject(s) - medicine , diabetes mellitus , transaminase , clinical trial , insulin , mode of action , intensive care medicine , endocrinology , toxicology , biology , biochemistry , enzyme
SUMMARY A brief review is given of recent claims that certain sulphonylurea compounds possess hypoglycMmic action. The results of clinical trials in the Diabetic and Metabolic Unit of the Alfred Hospital are presented. Clinical trials were undertaken on a selected group of 26 patients (18 females and eight males) and a satisfactory therapeutic response was obtained in 19 patients (13 females and six males). In the remaining patients treatment was regarded as a failure. The possible mode of action of sulphonylurea drugs is considered, and evidence is presented which suggests interference with transaminase systems in the liver. The conclusion is reached that these drugs do not act as substitutes for insulin, and that in view of side effects and the uncertain sequelM which may follow their prolonged administration, further work is necessary before they are made available for general use.