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URIC ACID AND THE URICASE‐RESISTANT RESIDUE IN RENAL INSUFFICIENCY
Author(s) -
GROSS R.,
BOLLIGER A.
Publication year - 1957
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1957.6.1.64
Subject(s) - uric acid , pathogenesis , medicine , urate oxidase , endocrinology , chemistry , biochemistry , gastroenterology
Summary After the destruction of uric acid in blood serum with the enzyme uricase, there remains a uricase‐resistant chromogen, which reacts with the phosphotungstate reagent used for uric acid determinations. Expressed as uric acid, the amount of this chromogen was almost negligible in 45 normal subjects, but was greatly increased (that is, up to eight milligrammes per 100 millilitres of serum) in renal insufficiency. Still higher values were encountered in a case of lethal eclampsia. In two cases of renal failure serial determinations of this chromogen were made, and it appeared to vary with the severity of the disease. The nature of this substance, which may play a significant role in the pathogenesis of renal failure, is unknown.