Premium
Essentials of a new clinical practice guidance on familial hypercholesterolaemia for physicians
Author(s) -
Watts Gerald F.,
Sullivan David R.,
Hare David L.,
Kostner Karam M.,
Horton Ari E.,
Bell Damon A.,
Brett Tom,
Trent Ronald J.,
Poplawski Nicola K.,
Martin Andrew C.,
Srinivasan Shubha,
Justo Robert N.,
Chow Clara K.,
Pang Jing
Publication year - 2021
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.15327
Subject(s) - medicine , ezetimibe , pcsk9 , familial hypercholesterolemia , clinical practice , genetic testing , intensive care medicine , disease , family medicine , statin , cholesterol , pathology , ldl receptor , lipoprotein
Familial hypercholesterolaemia (FH) is a common, heritable and preventable cause of premature coronary artery disease. New clinical practice recommendations are presented to assist practitioners in enhancing the care of all patients with FH. Core recommendations are made on the detection, diagnosis, assessment and management of adults, children and adolescents with FH. Management is under‐pinned by the precepts of risk stratification, adherence to healthy lifestyles, treatment of non‐cholesterol risk factors and appropriate use of low‐density lipoprotein (LDL)‐cholesterol‐lowering therapies including statins, ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. The recommendations need to be utilised using judicious clinical judgement and shared decision‐making with patients and families. New government‐funded schemes for genetic testing and use of PCSK9 inhibitors, as well as the National Health Genomics Policy Framework, will enable adoption of the recommendations. However, a comprehensive implementation science and practice strategy is required to ensure that the guidance translates into benefit for all families with FH.