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Anti‐MDA5‐associated dermatomyositis
Author(s) -
Gupta Rajiv,
Kumar Sunil,
Gow Peter,
HsienCheng Chang Leon,
Yen Linda
Publication year - 2020
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.14789
Subject(s) - medicine , dermatomyositis , interstitial lung disease , mda5 , myositis , concomitant , dermatology , refractory (planetary science) , lung , rna , biochemistry , chemistry , rna interference , gene , physics , astrobiology
Abstract Anti‐MDA5‐associated dermatomyositis (MDA5‐associated DM) is an uncommon presentation of idiopathic inflammatory myositis, typically amyopathic, associated with rapidly progressive, treatment refractory interstitial lung disease and poor prognosis, particularly in patients with concomitant rapidly progressive interstitial lung disease (RP‐ILD). We report two cases of MDA5‐associated DM with fatal outcome in one of the patients, despite ‘aggressive triple therapy’ for RP‐ILD.