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Comparison of the effects of oral iron treatment every day and every other day in female patients with iron deficiency anaemia
Author(s) -
Düzen Oflas Nur,
Demircioğlu Sinan,
Yıldırım Doğan Narin,
Eker Elife,
Kutlucan Ali,
Doğan Ali,
Aslan Mehmet,
Demir Cengiz
Publication year - 2020
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.14766
Subject(s) - medicine , ferrous , ferrous sulphate , ferritin , iron deficiency , iron supplementation , zoology , anemia , gastroenterology , chemistry , inorganic chemistry , organic chemistry , biology
Background It is known that daily divided doses and high doses of iron increase hepcidin and reduce iron absorption. Aim To compare treatments of iron replacement every other day at low doses, once a day and twice a day in terms of their effectiveness and frequencies of side‐effects. Methods For 1 month, Group I received 270 mg ferrous sulphate twice a day (total elemental iron dose: 160 mg/day), Group II received 270 mg ferrous sulphate once a day (total elemental iron dose: 80 mg/day), and Group III received 270 mg ferrous sulphate every other day (total elemental iron dose: 80 mg/every other day). Intragroup and intergroup statistical analyses were carried out. Results Haemoglobin (Hb) increased significantly in all three groups ( P = 0.00). The increase in Hb levels was similar among the groups ( P = 0.09). Ferritin significantly increased in all three groups after the treatment ( P = 0.00). The increase in ferritin in Group I was significantly higher than those in Groups II and III ( P < 0.05). Gastrointestinal tract (GIS) side‐effects were also significantly higher in Group I in comparison to the others ( P = 0.001). Conclusions A low dosage of iron treatment every other day may be used in the place of providing iron once or twice every day with similar effectiveness and lower rates of GIS side‐effects.