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Characteristics and outcomes of patients with acute liver failure admitted to Australian and New Zealand intensive care units
Author(s) -
Warrillow Stephen,
Bailey Michael,
Pilcher David,
Kazemi Alex,
McArthur Colin,
Young Paul,
Bellomo Rinaldo
Publication year - 2019
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.14167
Subject(s) - medicine , liver transplantation , incidence (geometry) , odds ratio , intensive care , transplantation , mortality rate , liver failure , pediatrics , intensive care medicine , physics , optics
Background Knowledge about patients with acute liver failure (ALF) in Australia and New Zealand (ANZ) is lacking. Aims To evaluate whether the pattern of ALF would be similar to previous studies and whether, despite potentially low transplantation rates, mortality would be comparable. Methods We obtained data from the ANZ Intensive Care Society Adult Patient Database and the ANZ Liver Transplant Registry for 10 years commencing 2005 and analysed for patient outcomes. Results During the study period, 1 022 698 adults were admitted to intensive care units across ANZ, of which 723 had ALF. The estimated annual incidence of ALF over this period was 3.4/million people and increased over time ( P = 0.001). ALF patients had high illness severity (Acute Physiology And Chronic Health Evaluation III 79.8 vs 50.1 in non‐ALF patients; P < 0.0001) and were more likely to be younger, female, pregnant and immunosuppressed. ALF was an independent predictor of mortality (odds ratio 1.5 (1.26–1.79); P < 0.0001). At less than 23%, the use of liver transplantation was low, but the mortality of 39% was similar to previous studies. Conclusions ALF is a rare but increasing diagnosis in ANZ intensive care units. Low transplantation rates in ANZ for ALF do not appear to be associated with higher mortality rates than reported in the literature.