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Rescue haploidentical peripheral blood stem cell transplantation for engraftment failure: a single‐centre case series
Author(s) -
Kliman David,
Bilmon Ian,
Kwan John,
Blyth Emily,
Micklethwaite Ken,
Panicker Shyam,
Bhattacharyya Abir,
Deren Stephanie,
Antonenas Vicki,
Huang Gillian,
Gottlieb David
Publication year - 2018
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.13979
Subject(s) - medicine , stem cell , sepsis , transplantation , peripheral blood stem cells , surgery , hematopoietic stem cell transplantation , genetics , biology
Graft failure affects approximately 5% of allogeneic stem cell transplants, with a poor prognosis. Salvage second allogeneic stem cell transplantation (alloSCT2) is limited by high rates of transplant‐related mortality from infection and graft‐versus‐host disease. We report on five adult patients receiving rescue alloSCT2 using haploidentical peripheral blood stem cells. All patients achieved neutrophil engraftment, two subsequently died from sepsis and disease relapse, respectively. Three patients remain alive up to 2 years post‐transplant. We suggest consideration of haploidentical alloSCT2 for patients with graft failure.