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Hypothalamic demyelination causing panhypopituitarism
Author(s) -
DixonDouglas Julia,
Burgess John,
Dreyer Michael
Publication year - 2018
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.13787
Subject(s) - medicine , hypopituitarism , neuromyelitis optica , multiple sclerosis , spectrum disorder , differential diagnosis , alemtuzumab , diabetes insipidus , pediatrics , pathology , immunology , psychiatry , antibody
Hypothalamic involvement in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) is rare and endocrinopathies involving the hypothalamic–pituitary axis in patients with demyelinating conditions have rarely been reported. We present two cases of MS/NMOSD with associated hypothalamic–pituitary involvement and subsequent hypopituitarism, including the first report of a patient with hypothalamic demyelination causing panhypopituitarism. Differential diagnoses, including alemtuzumab‐related and primary pituitary pathology are discussed.