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Severe methanol poisoning with neurological sequelae: implications for diagnosis and management
Author(s) -
Holt Nicolette R.,
Nickson Christopher P.
Publication year - 2018
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.13725
Subject(s) - medicine , mydriasis , antidote , coma (optics) , methanol poisoning , intensive care medicine , visual impairment , presentation (obstetrics) , anesthesia , toxicity , pediatrics , surgery , psychiatry , methanol , chemistry , physics , organic chemistry , optics
A 22‐year‐old woman presented with methanol toxicity manifesting as headache, reduced conscious state and visual change after consuming home‐made grappa. She progressed to a coma with fixed mydriasis and severe acidaemia (pH 6.55). She was treated with empirical antidote administration (intravenous ethanol) and enhanced elimination through haemodialysis. She survived despite her delayed presentation but developed significant neurological sequelae, including visual impairment. We provide an overview of key elements of diagnosis and recent updates in treatment recommendations.