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High urinary interleukin‐8 levels is associated with poor prognosis in idiopathic membranous nephropathy
Author(s) -
Chen Jilin,
Fu Xiaoye,
Sun Yanling,
Zhang Shengkun,
Xie Hua,
Lin Hongli
Publication year - 2018
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.13698
Subject(s) - medicine , membranous nephropathy , urinary system , interleukin , nephropathy , immunology , glomerulonephritis , endocrinology , kidney , cytokine , diabetes mellitus
Biomarkers required to assess accurately the prognosis of idiopathic membranous nephropathy (IMN) are still unavailable. A retrospective study on 156 IMN patients showed only urinary IL‐8 was associated with the achievement of initial complete remission (CR) in IMN patients. A urinary IL‐8 level of less than 61.25 pg/mL was more sensitive for prediction of CR in IMN patients. Therefore, urinary IL‐8 may be a potential biomarker for evaluating short‐term prognosis of IMN patients.