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Examining the impact of regular aspirin use and PIK3CA mutations on survival in stage 2 colon cancer
Author(s) -
Murphy Caitlin,
Turner Natalie,
Wong HuiLi,
Sinnathamby Mathu,
Tie Jeanne,
Lee Belinda,
Desai Jayesh,
Skinner Iain,
Christie Michael,
Hutchinson Ryan,
Lunke Sebastian,
Waring Paul,
Gibbs Peter,
Tran Ben
Publication year - 2017
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.13312
Subject(s) - medicine , aspirin , stage (stratigraphy) , cancer , colorectal cancer , oncology , paleontology , biology
Background/Aim Data suggest aspirin improves survival in colorectal cancer ( CRC ) harbouring PIK3CA mutations. The impact of aspirin is thought predominantly to be through an anti‐inflammatory effect. The aim of this study is to explore the effect of aspirin use on survival in a real‐world cohort of stage 2 colon cancer ( CC ) patients. Methods A prospective CRC database identified patients diagnosed with stage 2 CC between 2000 and 2011. PIK3CA mutation status was determined by next generation sequencing. Neutrophil‐lymphocyte ratio greater than 5 at diagnosis represented systemic inflammation. Chart review was used to record regular aspirin use at diagnosis. Clinico‐pathological features and survival data were available. Survival analyses used the Cox proportional hazards method. Results Of 488 patients with stage 2 CC , 95 patients were aspirin users and 70 patients had PIK3CA mutations. Aspirin users were more likely to be older (median: 76.4 years vs 68.3 years, P < 0.001), to be less fit (American Society of Anaesthetists Score 3–4: 58% vs 31%, P < 0.001) and to have systemic inflammation (neutrophil‐lymphocyte ratio > 5: 39% vs 27%, P = 0.027). Regular aspirin use did not significantly improve recurrence‐free survival. In the PIK3CA mutated group, there was a trend towards improved recurrence‐free survival (hazard ratio: 0.45, P = 0.42). Conclusions Our study did not demonstrate a significant survival advantage from aspirin use in stage 2 PIK3CA mutated CC . The ‘real‐world’ nature of our cohort and the subsequent uncontrolled differences in age and fitness in aspirin users are likely to have contributed to this result. Defining the true impact of aspirin in CRC requires prospective randomised clinical trials.