Premium
Association of the Glu504Lys polymorphism in the aldehyde dehydrogenase 2 gene with endothelium‐dependent dilation disorder in Chinese Han patients with essential hypertension
Author(s) -
Ma X.,
Zheng S.,
Shu Y.,
Wang Y.,
Chen X.
Publication year - 2016
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.12983
Subject(s) - aldh2 , medicine , odds ratio , confidence interval , essential hypertension , genotype , gastroenterology , blood pressure , allele , polymorphism (computer science) , endocrinology , aldehyde dehydrogenase , gene , genetics , biology
Background In essential hypertension ( EH ), 30–50% of the variability in blood pressure is determined by genetic factors. The aldehyde dehydrogenase 2 ( ALDH2 ) gene Glu504Lys polymorphism is associated with ‘alcohol flush’ and might be associated with EH . Aims The aim of the present study was to investigate the association of the Glu504Lys polymorphism in the ALDH2 gene with endothelium‐dependent dilation ( EDD ) disorder in Chinese Han patients with EH . Methods This case–control study enrolled 1210 patients with EH . The control group consisted of 1089 healthy subjects with normal blood pressure. Patients with EH were divided into normal brachial arterial flow‐mediated dilation ( FMD ) ( EH1 group, n = 354) versus endothelial dysfunction ( EH2 group, n = 856). ALDH2 gene Glu504Lys polymorphism was detected using a DNA microarray. Results The ALDH2 AA / AG genotypes and the A allele frequencies were significantly higher in the EH group compared with healthy controls (both P < 0.05) and significantly higher in the EH2 group compared with the EH1 group (79.8 vs 51.4%; 45.0 vs 29.1%, respectively; both P < 0.05). Multivariate logistic regression analyses showed that the ALDH2 gene Glu504Lys polymorphism was independently associated with EH (dominant: odds ratio ( OR ) = 1.38; 95% confidence interval (95% CI ) = 1.14–2.82; P = 0.01; additive: OR = 1.32; 95% CI = 1.12–2.44; P = 0.02) as well as with EDD in patients with EH (dominant: OR = 1.49, 95% CI = 1.16–3.01, P = 0.02; additive: OR = 1.43, 95% CI = 1.10–2.87, P = 0.03). Conclusion The ALDH2 Glu504Lys polymorphism was associated with EDD disorders in Chinese Han patients with EH , providing further evidence that this mutation and ‘alcohol flush’ are not harmless in this Asian population.