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Disseminated M ycobacterium haemophilum skeletal disease in a patient with interferon‐gamma deficiency
Author(s) -
Otome O.,
O'Reilly M.,
Lim L.
Publication year - 2015
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.12875
Subject(s) - medicine , autoantibody , immunology , immunodeficiency , interferon gamma , immunopathology , disease , antibody , immune system
Disseminated non‐tuberculous mycobacterial ( NTM ) infection is rare in immunocompetent adults. Anti‐interferon‐gamma ( IFN ‐γ) autoantibodies have recently been associated with NTM infections, particularly in patients of Asian ethnicity. We describe a case of disseminated Mycobacterium haemophilum skeletal infection due to anti IFN ‐γ autoantibodies in a 71‐year‐old C ambodian man. He responded to a combination of anti‐mycobacterial antibiotics without requirement for immunomodulator therapy. Testing for acquired IFN ‐γ deficiency due to IFN ‐γ autoantibodies should be considered when standard tests for immunodeficiency are negative in patients with unusual or severe opportunistic infections, including NTM .