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Primary central nervous system posttransplantation lymphoproliferative disorder after heart and lung transplantation
Author(s) -
Gifford G.,
Fay K.,
Jabbour A.,
Ma D. D.
Publication year - 2015
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.12735
Subject(s) - medicine , lung transplantation , central nervous system , lung , lymphoproliferative disorders , transplantation , heart transplantation , intensive care medicine , pathology , lymphoma
Primary central nervous system posttransplantation lymphoproliferative disorder ( PCNS‐PTLD ) is uncommon, especially after heart or lung transplantation. Database analysis from a single heart and lung transplantation centre and a literature review pertaining to PCNS‐PTLD was performed. In this study, the prevalence of PCNS‐PTLD was 0.18% after heart and/or lung transplants. Of 1674 transplants, three cases of PCNS‐PTLD developed 14 months, 9 years and 17 years posttransplant, and all were Epstein–Barr virus driven malignancies. Literature review of the topic revealed predominantly retrospective studies, with most reported cases after renal transplantation. The overall survival is poor, and it may be improved by early diagnosis and treatment. There are no published guidelines on the management of PCNS‐PTLD ; immune‐chemotherapy in conjunction with reduction of immune suppression is preferred based on available evidence.