Premium
Crescentic glomerulonephritis: data from the S panish G lomerulonephritis R egistry
Author(s) -
Quiroga B.,
Vega A.,
Rivera F.,
LópezGómez J. M.
Publication year - 2015
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.12725
Subject(s) - medicine , glomerulonephritis , renal biopsy , proteinuria , renal function , glomerular basement membrane , immune system , gastroenterology , kidney , pathology , immunology
Background Crescentic glomerulonephritis ( CGN ) is a histological finding that implies rapid deterioration of renal function and can be related to different diseases, such as type 1 or anti‐glomerular basement membrane antibody ( G oodpasture) disease, type 2 or immune complex CGN and type 3 or pauci‐immune disease. Aim The present study describes CGN and its characteristics based on the data from the S panish G lomerulonephritis R egistry. Methods An analysis was made of all native renal biopsies obtained from patients during 1994–2013 and classified as CGN . A patient epidemiological and clinical data questionnaire was completed by the 120 centres involved. Results A total of 21 774 biopsies was performed, of which 2089 (8.1%) corresponded to CGN (211 type 1, 177 type 2 and 1701 type 3). Renal function was poorer in type 1 compared with types 2 and 3, and proteinuria was higher in type 2 compared to types 1 and 3. Patients diagnosed with CGN type 3 were older than those with types 1 and 2, but less hypertensive than the type 2 patients. No differences in the urine test findings were found between types 1 and 2. Microhaematuria was the most frequent feature in general, as well as in type 3 compared with types 1 and 2. The main indication for biopsy was acute renal injury. Age was the only difference between type 1 patients with and without alveolar haemorrhage (53 [33–67] vs 64 [46–73], P = 0.008). Conclusion Although classified as the same entity, the different types of CGN have different features that must be taken into account.