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Macro‐creatine kinase: a neglected cause of elevated creatine kinase
Author(s) -
Aljuani F.,
Tournadre A.,
Cecchetti S.,
Soubrier M.,
Dubost J. J.
Publication year - 2015
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.12710
Subject(s) - medicine , discontinuation , creatine kinase , rheumatoid arthritis , myositis , surgery
Macro‐creatine kinase (macro‐ CK ) is a neglected cause of raised CK . Over a 10‐year period, we observed five cases. Three patients had macro‐ CK type 1. One patient with fibromyalgia underwent several explorations to find a muscular pathology; another, who had elevated CK‐MB (muscle–brain fraction) activity, was referred to a cardiologist, and statin therapy was erroneously discontinued in two patients. Two patients had macro‐ CK type 2: a man with a neuroendocrine carcinoma and a woman with rheumatoid arthritis. Diagnosis of type 1 obviates the need to carry out pointless and expensive investigations seeking a neuromuscular or cardiac pathology, and also, the unwarranted discontinuation of statin therapy. Type 2 must prompt investigations for a neoplasm.