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Early and late changes in markers of aortic stiffness with breast cancer therapy
Author(s) -
Grover S.,
Lou P. W.,
Bradbrook C.,
Cheong K.,
Kotasek D.,
Leong D. P.,
Koczwara B.,
Selvanayagam J. B.
Publication year - 2015
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.12645
Subject(s) - medicine , pulse wave velocity , cardiology , breast cancer , trastuzumab , arterial stiffness , cancer , anthracycline , aorta , chemotherapy , blood pressure
Background Anthracyclines and trastuzumab are well recognised to cause cardiac toxicity. Further to their effects on left ventricular ( LV ) function, anthracyclines in particular are considered to cause negative arterial remodelling. Whether these changes reverse is unknown. In addition, whether trastuzumab causes specific effects on arterial remodelling is yet undetermined. Methods Patients receiving these agents for treatment of breast cancer and healthy volunteers prospectively underwent clinical evaluation and cardiovascular magnetic resonance ( CMR ) imaging at baseline, 1, 4 and 14 months post‐therapy, including functional assessment, measurement of aortic pulse wave velocity ( PWV ) using velocity encoded imaging and distensibility at ascending aorta ( AA ) and proximal descending aorta ( PDA ). Results Twenty‐nine patients pretherapy and 12 volunteers demonstrated no differences in PWV , distensibility and LV function. Among cancer subjects, PWV increased acutely, P = 0.002 (4 months), then decreased by 14 months ( P < 0.001). In addition, a decrease was observed in distensibility at the AA within 1 ( P = 0.001) and 4 months ( P < 0.001) of commencing therapy. At the PDA , only significant reduction was observed at 14 month distensibility when compared with baseline, P < 0.001. Patients with anthracycline exposure only had a greater reduction in aortic distensibility in the AA with time, P = 0.005 at 1 month, P < 0.001 at 4 months and P = 0.009 at 14 months. Conclusion Acute changes are observed in PWV and distensibility at the AA following contemporary breast cancer chemotherapy and partially reverse a year after therapy is discontinued, with more severe effects seen with anthracyclines.