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A possible role of serum uric acid as a marker of metabolic syndrome
Author(s) -
Lee Y.J.,
Cho S.,
Kim S. R.
Publication year - 2014
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.12588
Subject(s) - medicine , metabolic syndrome , uric acid , hazard ratio , biomarker , diabetes mellitus , hyperuricemia , receiver operating characteristic , retrospective cohort study , cohort , cohort study , endocrinology , confidence interval , biochemistry , chemistry
Background/Aims The association between serum uric acid ( SUA ) levels and metabolic syndrome ( MetS ) has recently been reported in several cross‐sectional and longitudinal studies. We investigated SUA as a biomarker to predict future development of MetS in healthy K orean men without diabetes or hypertension and determined the optimal cut‐off levels of SUA . Methods A retrospective cohort study was conducted using data from healthy men who received a general health check‐up in 2003. A total of 1809 participants free of MetS , diabetes and hypertension was enrolled. Participants were classified into three groups based on SUA levels: group 1 (<5.5 mg/d L ), group 2 (5.5–6.9 mg/d L ) and group 3 (≥7.0 mg/d L ). Results During 13 802 person‐years of follow up, 127 participants developed MetS . After adjusting for multiple associated parameters, SUA was significantly associated with incident MetS (hazard ratios comparing groups 2 and 3 vs group 1, 2.45 and 3.47 respectively; P < 0.001). In receiver operating characteristic curve analysis, the optimal cut‐off level for SUA to predict the development of MetS was 6.5 mg/d L . Conclusion Our results indicate that an increased level of SUA , even within the normal range, is associated with future development of MetS in healthy middle‐aged men.