Premium
Assessment of renal involvement in patients with familial M editerranean fever: a clinical study from A rdabil, I ran
Author(s) -
Bashardoust B.,
Maleki N.
Publication year - 2014
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.12520
Subject(s) - medicine , familial mediterranean fever , focal segmental glomerulosclerosis , colchicine , amyloidosis , membranoproliferative glomerulonephritis , differential diagnosis , kidney , pathology , glomerulonephritis , gastroenterology , disease
Background and Aim Familial M editerranean fever ( FMF ) is an autosomal recessive disease characterised by recurrent episodes of painful inflammation in the abdomen, chest or joints. The association between FMF and non‐amyloid glomerulopathies are unusual. In this study, we describe our experiences and observations about renal involvement in patients with FMF . Methods A total of 108 patients with FMF was enrolled in the study. Twelve patients with FMF were referred to the N ephrology S ervice, for evaluation and assessment of the degree of renal involvement. All the 12 patients underwent percutaneous ultrasound‐guided renal biopsies and genetic analysis. Results On microscopic examination of the kidney specimens, six patients were found to have amyloidosis, five focal segmental glomerulosclerosis and one patient membranoproliferative glomerulonephritis. It seems that in patients with FMF and renal amyloidosis, the response to treatment with colchicine is excellent, but in patients with FMF and focal segmental glomerulosclerosis, the response to treatment with colchicine is poor. We present an evidence‐based algorithm, constructed based on literature review, to aid decision making in management of renal involvement in patients with FMF . Conclusion The results of our study suggest that in patients with FMF and renal involvement, non‐amyloid renal lesions should be considered in the differential diagnosis in addition to amyloidosis.