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Liver transplantation for the treatment of homozygous familial hypercholesterolaemia in an era of emerging lipid‐lowering therapies
Author(s) -
Page M. M.,
Ekinci E. I.,
Jones R. M.,
Angus P. W.,
Gow P. J.,
O'Brien R. C.
Publication year - 2014
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.12444
Subject(s) - medicine , familial hypercholesterolemia , liver transplantation , apheresis , transplantation , ldl apheresis , coronary artery disease , lipoprotein , cholesterol , pharmacology , platelet
Homozygous familial hypercholesterolaemia ( FH ) causes severe premature coronary artery disease because of very high levels of low density lipoprotein (LDL)‐cholesterol. Standard lipid‐lowering drugs and LDL ‐apheresis may not be sufficiently effective. Liver transplantation replaces defective LDL receptors and vastly improves the lipid profile, and we present the first report of an A ustralian adult to receive this treatment. Emerging drug treatments for FH may be alternatives to LDL ‐apheresis and transplantation, but long‐term safety and efficacy data are lacking for all of these options.