Premium
Cardiac sarcoidosis: the Christchurch experience
Author(s) -
Adamson P.,
Melton I.,
O'Donnell J.,
MacDonald S.,
Crozier I.
Publication year - 2014
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.12314
Subject(s) - medicine , cardiology , presyncope , cardiac sarcoidosis , asymptomatic , heart failure , sarcoidosis , atrial fibrillation , ventricular tachycardia , cardiac magnetic resonance imaging , ventricular fibrillation , atrioventricular block , heart block , electrocardiography , magnetic resonance imaging , radiology , heart rate , blood pressure
Background and aims To present an overview of the diagnosis, treatment and outcomes of patients with cardiac sarcoidosis managed in C hristchurch H ospital, N ew Z ealand. Methods A retrospective review of patients with cardiac sarcoidosis at C hristchurch H ospital from J anuary 2005 to D ecember 2012. Results Eighteen patients were identified with cardiac sarcoidosis. All the 12 patients that underwent cardiac magnetic resonance imaging ( CMR ) had abnormal scans. Angiotensin‐converting enzyme (ACE) levels were elevated in 4 of 16 patients and troponin (cTn) was elevated in 5 of 15 patients. Endomyocardial biopsies were diagnostic in two of six patients. The principal causes for presentation related to symptomatic high‐grade atrioventricular conduction block and congestive heart failure with six patients in each of these groups. In addition, three patients presented with ventricular tachycardia and the remaining three patients presented with atrial fibrillation, recurrent presyncope without proven heart block and an asymptomatic persistent elevation of cardiac troponin. Seven patients had pre‐existing, extra‐cardiac sarcoidosis and a concomitant diagnosis was made in a further eight cases. Three patients had isolated cardiac involvement at presentation. Sixteen patients received immunosuppressive therapy. Twelve patients had cardiac devices implanted; five pacemakers, five defibrillators and two resynchronising pacemaker defibrillators. During follow up for 0.1–30.8 years, median 4.8 years, two patients died. Conclusions In our patients CMR demonstrated high diagnostic sensitivity, while biomarkers ( ACE and cTn ) were frequently within the normal reference range. Cardiac sarcoidodis caused major arrhythmias or heart failure in the majority of patients. Most patients were treated with immunosuppression and cardiac device therapy. Long‐term mortality was lower than previously reported.