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Volunteer unrelated donor experience after administration of filgrastim and apheresis for the collection of haemopoietic stem cells: the A ustralian perspective
Author(s) -
Gordon S. V.,
NivisonSmith I.,
Szer J.,
Chapman J. R.
Publication year - 2013
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.12282
Subject(s) - medicine , filgrastim , apheresis , granulocyte colony stimulating factor , volunteer , adverse effect , bone marrow , donation , incidence (geometry) , prospective cohort study , surgery , chemotherapy , platelet , physics , optics , agronomy , economics , biology , economic growth
Abstract Background Voluntary donations of peripheral blood stem cells after administration of filgrastim (granulocyte‐colony stimulating factor, G‐CSF ) are undertaken throughout the world by healthy individuals, but the short‐, medium‐ and long‐term adverse events during and after donation are not fully understood. Aims We document the experience of donors of peripheral blood stem cells mobilised by G‐CSF at A ustralian B one M arrow D onor R egistry collection centres. Methods When the A ustralian B one M arrow D onor R egistry commenced collecting mobilised peripheral blood stem cells, based on data used for registration of G‐CSF , all adverse reactions in donors were documented prospectively to determine the rate and severity of events. A total of 512 consecutive first‐time donors assessed between J uly 2001 and M arch 2010 were included in this study. Results The median age at work‐up was 40 years and 71% of donors were male. A large proportion of donors (91%) experienced bone pain during administration of G‐CSF , and in fewer numbers headache (61%) and fatigue (61%). Bone pain was associated with a body mass index of overweight/obese ( P = 0.03). Headache ( P = 0.03), muscle pain ( P = 0.03) and fatigue ( P = 0.001) were all significantly associated with female sex. More than a quarter (28%) of donations involved a range of complications at collection. Conclusion The incidence of short‐ and medium‐term symptoms and events observed provide support for the information provided to unrelated donors at counselling. Follow up of the consequences of unrelated voluntary donation remains important to provide accurate and relevant information to prospective donors.