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Prolonged vitamin D intoxication: presentation, pathogenesis and progress
Author(s) -
Bell D. A.,
Crooke M. J.,
Hay N.,
Glendenning P.
Publication year - 2013
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.12269
Subject(s) - medicine , hypercalcaemia , vitamin d and neurology , toxicity , parathyroid hormone , vitamin , pathogenesis , vitamin d deficiency , endocrinology , calcium
Abstract Vitamin D toxicity from unactivated vitamin D (calciferol) therapy is currently a rare cause of hypercalcaemia. However, the frequency of this event may increase as high‐dose unactivated vitamin D preparations become available. Prolonged vitamin D toxicity can cause reversible hypercalcaemia and partially reversible renal impairment. Parathyroid hormone may not be suppressed with unactivated vitamin D toxicity, especially if renal disease coexists.