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Peripheral T ‐cell lymphoma mimicking 5‐aminosalicylate hypersensitivity in ulcerative colitis
Author(s) -
Kong L. M.,
Fok K. C.,
Tsui A.,
Qian C.,
Fisher L.
Publication year - 2013
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.12240
Subject(s) - medicine , sulfasalazine , ulcerative colitis , lymphoma , malignancy , allergy , hypersensitivity reaction , gastroenterology , peripheral t cell lymphoma , adverse effect , colitis , adverse drug reaction , drug , immunology , dermatology , t cell , pharmacology , immune system , disease
5‐aminosalicylates (5‐ ASA ) remain an important strategy in the induction and maintenance of remission of inflammatory bowel diseases especially in ulcerative colitis. The prototypical drug of this class, sulfasalazine is generally well tolerated with severe hypersensitivity reactions and hepatotoxicity also described within the literature. When approaching a patient with an adverse reaction to 5‐ ASA , it can be difficult to differentiate clinically between a sulfa allergy versus a 5‐ ASA allergy versus a malignancy. We report on a case with initial signs and symptoms suggestive of a sulfa/5‐ ASA allergy that was subsequently found to be malignant in nature.