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A sian ethnicity in systemic lupus erythematosus: an A ustralian perspective
Author(s) -
Connelly K.,
Morand E. F.,
Hoi A. Y.
Publication year - 2013
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/imj.12070
Subject(s) - medicine , ethnic group , context (archaeology) , disease , systemic lupus erythematosus , epidemiology , autoantibody , immunology , cohort , lupus erythematosus , pathogenesis , perspective (graphical) , antibody , paleontology , sociology , anthropology , biology , artificial intelligence , computer science
Ethnic differences in both disease susceptibility and expression have been noted in systemic lupus erythematosus ( SLE ). This review focuses on the evidence of disparities between SLE patients of A sian and C aucasian descent, the two predominant ethnic groups affected by SLE in the A ustralian context. While epidemiological studies suggest higher rates of SLE among A sian patients, multi‐ethnic cohort studies have allowed direct comparison of disease characteristics between different ethnic groups. Such studies suggest that A sians are affected by more severe SLE across several disease parameters, including increased renal involvement, autoantibody positivity, disease activity and damage accumulation. As delineation of these disparities becomes clearer, uncovering the biological basis of such differences poses a significant opportunity to progress understanding of SLE pathogenesis. Understanding ethnic variation in disease provides a platform for an individualised approach to risk assessment, monitoring and management of SLE .