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Autophagy in T‐cell differentiation, survival and memory
Author(s) -
Wang Liqing,
Das Jugal Kishore,
Kumar Anil,
Peng HaoYun,
Ren Yijie,
Xiong Xiaofang,
Yang JinMing,
Song Jianxun
Publication year - 2021
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/imcb.12422
Subject(s) - autophagy , microbiology and biotechnology , biology , immune system , programmed cell death , immunotherapy , cell , cancer immunotherapy , cellular differentiation , cell fate determination , inflammation , mechanism (biology) , apoptosis , immunology , genetics , transcription factor , gene , philosophy , epistemology
Over the past decade, autophagy has emerged as a critical regulatory mechanism of the immune system through critically controlling various aspects of T cell biology and determining the fate of different T cell subsets. Autophagy maintains T cell development and survival by regulating the degradation of organelles and apoptotic proteins. The autophagic process also impacts the formation of memory T cells. Alteration of autophagy in T cells may lead to a variety of pathological conditions such as inflammation, autoimmune diseases and cancer. In this review, we discuss how autophagy impacts T cell differentiation, survival and memory, and its implication in immunotherapy for various diseases.