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The rise and fall of bone marrow plasma cells after influenza vaccination
Author(s) -
Koutsakos Marios,
Ellebedy Ali H
Publication year - 2021
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/imcb.12417
Subject(s) - vaccination , immunology , bone marrow , antibody , population , antigen , smallpox , medicine , virology , immunity , virus , biology , immune system , environmental health
A recent report by Davis et al. shows that following vaccination, B‐cell activation results in the emergence of a population of antibody‐secreting cells (plasmablasts – PBs) in blood and a population of plasma cells (PCs) in the bone marrow, which likely originate from the day 7 PBs. However, these newly arrived PCs do not become long‐lived and their abundance decreases by 1 year post‐vaccination.
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