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Bridging the gap – a new role for STAT3 in TLR4‐mediated metabolic reprogramming
Author(s) -
Weiss Hauke J,
O'Neill Luke AJ
Publication year - 2021
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/imcb.12414
Subject(s) - microbiology and biotechnology , innate immune system , tlr4 , biology , cytokine , receptor , macrophage , glycolysis , signal transduction , biochemistry , immunology , metabolism , in vitro
Balic et al . describe a new role for STAT3 in TLR4 signalling in macrophages, linking LPS mediated activation of this innate immune receptor to phosphorylation of mitochondrial STAT3, resulting in distinct metabolic reprogramming.
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