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NKG7 – regulating endosomal pathways?
Author(s) -
Schuster Iona S,
Andoniou Christopher E
Publication year - 2020
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/imcb.12403
Subject(s) - cytotoxic t cell , immune system , degranulation , proinflammatory cytokine , inflammation , regulator , biology , microbiology and biotechnology , endosome , immunology , antigen presentation , t cell , intracellular , biochemistry , receptor , gene , in vitro
Ng et al . have identified NKG7 as a regulator of inflammation in response to diverse immunological challenges. While NKG7 was required for the degranulation of cytotoxic cells, additional defects including reduced expansion and trafficking of CD8 T cells, and altered antigen presentation, were noted in NKG7‐deficient mice. The precise mechanism by which NKG7 mediates its effects has not been resolved but may involve regulation of endosomal vesicle trafficking.