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TANK‐binding kinase 1 mediates osteoclast differentiation by regulating NF‐κB, MAPK and Akt signaling pathways
Author(s) -
Lin Shuai,
Zhao Xiaoli,
Wang Zhen
Publication year - 2021
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/imcb.12401
Subject(s) - rankl , osteoclast , protein kinase b , tank binding kinase 1 , microbiology and biotechnology , iκb kinase , nf κb , kinase , signal transduction , mapk/erk pathway , chemistry , activator (genetics) , rank ligand , cancer research , biology , receptor , map kinase kinase kinase , biochemistry
TANK‐binding kinase 1 (TBK1) knockdown inhibits the receptor activator of nuclear factor‐κB (NF‐κB) ligand (RANKL)‐induced osteoclast (OC) differentiation and function. Downregulation of TBK1 greatly suppresses RANKL‐induced gene expressions correlated with OC differentiation. TBK1 mediates the OC differentiation and function by regulating NF‐κB, mitogen‐activated protein kinases and protein kinase B signals.