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Immunoglobulin E sialylation regulates allergic responses
Author(s) -
Xie Markus M,
Bertozzi Carolyn R,
Wang Taia T
Publication year - 2020
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/imcb.12368
Subject(s) - degranulation , immunoglobulin e , sialic acid , immunology , allergy , antibody , chemistry , biology , biochemistry , receptor
Shade et al. demonstrate that people with peanut allergies produce IgE antibodies that are enriched for sialic acid‐containing glycoforms. The sialylated IgE triggered significantly more degranulation by basophils and mast cells, suggesting intrinsic functional differences between IgEs from allergic and nonallergic subjects.