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The metabolic spectrum of memory T cells
Author(s) -
O'Sullivan David
Publication year - 2019
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/imcb.12274
Subject(s) - phenotype , context (archaeology) , cell metabolism , microbiology and biotechnology , biology , metabolic pathway , metabolism , function (biology) , memory cell , memory t cell , t cell , immunology , genetics , biochemistry , immune system , gene , paleontology , physics , transistor , quantum mechanics , voltage
The development and persistence of memory T cells are integral to effective host defenses. Cell metabolism has a central role in the maintenance of these populations and engagement of specific metabolic pathways can influence T‐cell fate. Nuances in memory T‐cell metabolism are both context dependent, and exist, on a spectrum that complements and supports the activity of specific memory T‐cell subsets. This review explores how metabolic pathways and substrate choice can influence the phenotype and function of memory T cells.