The metabolic spectrum of memory T cells | Zendy

O'Sullivan David | Zendy

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The metabolic spectrum of memory T cells

Author(s) -

O'Sullivan David

Publication year - 2019

Publication title -

immunology and cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.999

H-Index - 104

eISSN - 1440-1711

pISSN - 0818-9641

DOI - 10.1111/imcb.12274

Subject(s) - phenotype , context (archaeology) , biology , cell metabolism , microbiology and biotechnology , metabolic pathway , function (biology) , metabolism , memory cell , immunological memory , immunology , genetics , immune system , biochemistry , gene , immunity , paleontology , physics , transistor , quantum mechanics , voltage

The development and persistence of memory T cells are integral to effective host defenses. Cell metabolism has a central role in the maintenance of these populations and engagement of specific metabolic pathways can influence T‐cell fate. Nuances in memory T‐cell metabolism are both context dependent, and exist, on a spectrum that complements and supports the activity of specific memory T‐cell subsets. This review explores how metabolic pathways and substrate choice can influence the phenotype and function of memory T cells.

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