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Immunological effects of placental extracellular vesicles
Author(s) -
Tong Mancy,
Abrahams Vikki M,
Chamley Lawrence W
Publication year - 2018
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/imcb.12049
Subject(s) - extracellular vesicles , placenta , immune system , human placenta , pregnancy , immunology , biology , medicine , microbiology and biotechnology , fetus , genetics
Extracellular vesicles ( EV s) extruded by the human placenta are increasingly being recognized as an essential mode of feto‐maternal communication. In the past two decades, there has been an explosion of research into the roles that placental EV s play in modulating the maternal immune and cardiovascular systems during healthy pregnancies, as well as how this communication is altered in obstetric diseases. This review aims to introduce readers to the processes of placental EV formation and the cargos they carry, and also to collate and summarize the published literature that investigates the immunological effects of placental EV s throughout human pregnancy.