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Molecular control of B‐cell homeostasis in health and malignancy
Author(s) -
Garcillán Beatriz,
Figgett William A,
Infantino Simona,
Lim Ee Xin,
Mackay Fabienne
Publication year - 2018
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/imcb.12030
Subject(s) - autoimmunity , homeostasis , immune system , biology , cell , immunodeficiency , malignancy , immunology , microbiology and biotechnology , genetics
Altered B‐cell homeostasis underlies a wide range of pathologies, from cancers to autoimmunity and immunodeficiency. The molecular safeguards against those disorders, which also allow effective immune responses, are therefore particularly critical. Here, we review recent findings detailing the fine control of B‐cell homeostasis, during B‐cell development, maturation in the periphery and during activation and differentiation into antibody‐producing cells.