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Inflammatory monocytes contribute to the persistence of CXCR 3 hi CX 3 CR 1 lo circulating and lung‐resident memory CD 8 + T cells following respiratory virus infection
Author(s) -
Desai Pritesh,
Tahiliani Vikas,
Stanfield Jessica,
Abboud Georges,
SalekArdakani Shahram
Publication year - 2018
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/imcb.12006
Subject(s) - persistence (discontinuity) , chemistry , microbiology and biotechnology , biology , geotechnical engineering , engineering
Phenotypically diverse memory CD 8 + T cells are present in the lungs that either re‐circulate or reside within the tissue. Understanding the key cellular interactions that regulate the generation and then persistence of these different subsets is of great interest. Recently, DNGR ‐1 + dendritic cell ( DC ) mediated priming was reported to control the generation of lung‐resident but not circulating memory cells following respiratory viral infection. Here, we report an important role for Ly6C + inflammatory monocytes ( IM s) in contributing to the persistence of memory CD 8 + T cells but not their generation. Effector CD 8 + T cells expanded and contracted normally in the absence of IM s, but the memory compartment declined significantly over time. Quite unexpectedly, this defect was confined to tissue resident and circulating CXCR 3 hi CX 3 CR 1 lo memory cells but not CXCR 3 hi CX 3 CR 1 int and CXCR 3 lo CX 3 CR 1 hi subsets. Thus, two developmentally distinct innate cells orchestrate the generation and persistence of memory T cell subsets following a respiratory virus infection. See also: News and Commentary by Lafouresse & Groom