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PIKK ing a way to regulate inflammation
Author(s) -
Quek Hazel,
Lim Yi Chieh,
Lavin Martin F,
Roberts Tara L
Publication year - 2018
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/imcb.1001
Subject(s) - kinase , innate immune system , inflammation , biology , microbiology and biotechnology , immune system , signal transduction , computational biology , genetics , immunology
Abstract The phosphoinositide‐3‐kinase like kinases are a family of very large protein kinases. These PI 3‐kinase like kinase ( PIKK ) proteins have well‐established roles in detection and repair of damage to the genome, regulation of the transcriptome and cellular metabolism. Recently there has emerged, evidence for links between these proteins and inflammation. While some of these links come from an increased understanding of the impacts of damage to the cell on inflammatory responses, others suggest that PIKK proteins also have direct roles in regulation of immune responses. Particularly evident is the link between DNA damage and innate immune response pathways. Here, we review recent findings on the PIKK family of proteins and how they impact on inflammation, particularly activation of the innate immune system.