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Desmopressin response in nocturnal enuresis without nocturnal polyuria in Japanese children
Author(s) -
Akagawa Shohei,
Tsuji Shoji,
Akagawa Yuko,
Yamanouchi Sohsaku,
Kimata Takahisa,
Kaneko Kazunari
Publication year - 2021
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.14615
Subject(s) - desmopressin , medicine , polyuria , nocturia , urology , pediatrics , endocrinology , urinary system , diabetes mellitus
Objectives To evaluate whether the efficacy of desmopressin differs between patients with and without nocturnal polyuria. Methods A total of 65 treatment‐naïve children with monosymptomatic nocturnal enuresis were enrolled (45 boys; median age 8.9 years). Patients received desmopressin as their first‐line treatment. Four different standards were used (Akashi and Hoashi >0.9 mL/kg/sleeping hour; Hamano >[age + 2] × 25 × 130% mL; the International Children's Continence Society >[age + 1] × 30 × 130% mL; and Rittig >[age + 9] × 20 mL) to assess nocturnal polyuria. The effectiveness of desmopressin was compared between patients with and without nocturnal polyuria according to each standard. A response was defined as a reduction in wet nights of >50%. Results The desmopressin treatment efficacy rate was 54% for polyuria and 67% for non‐polyuria patients ( P = 0.20), 45% for polyuria and 68% for non‐polyuria patients ( P = 0.08), 54% for polyuria and 59% for non‐polyuria patients ( P = 0.80), and 52% for polyuria and 61% for non‐polyuria patients ( P = 0.61), for the Akashi and Hoashi's, Hamano's, International Children’s Continence Society and Rittig's standards, respectively. Conclusions No difference was observed in the short‐term clinical efficacy of desmopressin regardless of the presence of nocturnal polyuria. Thus, this might be a feasible treatment option for patients with nocturnal enuresis without nocturnal polyuria.