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Safety and mid‐term surgical results of anterior urethroplasty with the tissue‐engineered oral mucosa graft MukoCell ® : A single‐center experience
Author(s) -
Karapanos Leonidas,
Akbarov Ilgar,
Zugor Vahudin,
Kokx Ruud,
Hagemeier Anna,
Heidenreich Axel
Publication year - 2021
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.14606
Subject(s) - medicine , urethroplasty , interquartile range , surgery , urethral stricture , single center , perioperative , adverse effect , fistula , urethra
Objective To assess the mid‐term efficacy and safety of anterior urethroplasty using an autologous tissue‐engineered oral mucosa graft (MukoCell ® ). Methods The data of 77 patients with anterior urethral strictures undergoing treatment with MukoCell ® at a tertiary center from June 2016 to May 2019 were analyzed. Patients’ characteristics, pre‐ and postoperative diagnostics, perioperative complications, and follow‐up data were obtained. The overall stricture‐free survival, outcomes of the different surgical techniques, stricture localizations, stricture length, early complications of the procedure and risk factors of recurrence were assessed. Results The median follow‐up period was 38 months (interquartile range 31–46). The overall recurrence‐free rate of anterior urethroplasty using MukoCell ® was 68.8%, 24 patients (31.2%) developed a recurrence of the stricture. The stricture recurrences were observed at a median of 7 months (interquartile range 3–13) only in patients with at least one previous surgery or repeated dilatations in their medical history. No oral‐urethral adverse events related to the use of MukoCell ® were observed, except for a urethrocutaneous fistula (1.3%) requiring reoperation. Conclusions Anterior one‐stage urethroplasty using MukoCell ® showed in our hands a mid‐term success rate of up to 68.8% without significant adverse events after a median follow‐up period of 38 months. This procedure might be an alternative option for long‐segment urethral reconstruction.