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Male infertility in Sertoli cell‐only syndrome: An investigation of autosomal gene defects
Author(s) -
Koc Gulsah,
Ozdemir Abdullah A,
Girgin Gozde,
Akbal Cem,
Kirac Deniz,
Avcilar Tuba,
Guney Ahmet I
Publication year - 2019
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.13863
Subject(s) - genetics , biology , male infertility , loss of heterozygosity , gene , comparative genomic hybridization , sertoli cell , single nucleotide polymorphism , candidate gene , genome , spermatogenesis , infertility , allele , endocrinology , genotype , pregnancy
Objectives To detect autosomal genetic defects and to determine candidate genes in Sertoli cell‐only syndrome infertile men. Methods Single‐nucleotide polymorphism + comparative genomic hybridization microarray technology was carried out on 39 Sertoli cell‐only syndrome infertile patients in the present study. Array comparative genomic hybridization compares the patient's genome against a reference genome, and identifies uncover deletions, amplifications and loss of heterozygosity. Results A link between defective spermatogenesis genes and infertility was examined, and amplifications and deletions in several genes were detected, including homeobox gene; synaptonemal complex element protein 1; collagen, type I, alpha 1; imprinted maternally expressed transcript; and potassium voltage‐gated channel subfamily Q member 1. Conclusions The present data suggest that several genes can play an important role in spermatogenesis and progression of Sertoli cell‐only syndrome.