z-logo
Premium
Male infertility in Sertoli cell‐only syndrome: An investigation of autosomal gene defects
Author(s) -
Koc Gulsah,
Ozdemir Abdullah A,
Girgin Gozde,
Akbal Cem,
Kirac Deniz,
Avcilar Tuba,
Guney Ahmet I
Publication year - 2019
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.13863
Subject(s) - genetics , biology , male infertility , loss of heterozygosity , gene , comparative genomic hybridization , sertoli cell , single nucleotide polymorphism , candidate gene , genome , spermatogenesis , infertility , allele , endocrinology , genotype , pregnancy
Objectives To detect autosomal genetic defects and to determine candidate genes in Sertoli cell‐only syndrome infertile men. Methods Single‐nucleotide polymorphism + comparative genomic hybridization microarray technology was carried out on 39 Sertoli cell‐only syndrome infertile patients in the present study. Array comparative genomic hybridization compares the patient's genome against a reference genome, and identifies uncover deletions, amplifications and loss of heterozygosity. Results A link between defective spermatogenesis genes and infertility was examined, and amplifications and deletions in several genes were detected, including homeobox gene; synaptonemal complex element protein 1; collagen, type I, alpha 1; imprinted maternally expressed transcript; and potassium voltage‐gated channel subfamily Q member 1. Conclusions The present data suggest that several genes can play an important role in spermatogenesis and progression of Sertoli cell‐only syndrome.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here